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In vitro analysis reveals the structure and bioactivity of bacterial migrastatin in human tumor cells, suggesting potential therapeutic value against cancer cell migration.
Sir:Migrastatin (1), a novel 14-membered ring macrolide, was isolated from a culture broth of Streptomyces sp.MK929-43F1.1)It inhibits both anchorage-independent growth and migration of human tumor cells.2) Previously, we reported the planar structure and geometry of the three olefins in the 14-membered ring of 1.3)In this communication, we describe the absolute structure of 1 determined by X-ray crystallographic analysis as shown in Fig. 1.
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Nakamura et al. (2002) studied this question.
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