March 15, 2002Journal of Cell Science

Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae

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Why the study?

Does plasma membrane cholesterol content control EGFR activation in cells?

Population

Normal cells, cholesterol-depleted cells, and cholesterol-enriched cells

Comparison

Cholesterol depletion and cholesterol enrichment vs Normal cells

Design

Preclinical

Authors

TRTove RingerikeOslo University Hospital FBFrøydis D. BlystadThe University of Western Australia FLFinn Olav LevyOslo University Hospital

Discussion

Member takes

Implication

Supports membrane cholesterol as EGFR regulator in animal cells; leaves open human disease relevance and therapeutic potential.

Structured PICO

Does plasma membrane cholesterol content control EGFR activation in cells?

Population

Normal cells, cholesterol-depleted cells, and cholesterol-enriched cells

Intervention

Cholesterol depletion and cholesterol enrichment

Comparator

Normal cells

Outcome

Localization and function (activation/phosphorylation) of EGFRsurrogate

Plasma membrane cholesterol content directly controls EGFR activation, with cholesterol depletion leading to hyperphosphorylation and cholesterol enrichment reducing activation.

Cite This Study

Ringerike et al. (2002) studied this question.

synapsesocial.com/papers/6a8c29340ca85c7e33df2d74 https://doi.org/10.1242/jcs.115.6.1331

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Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider