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Fibromyalgia is associated with prominent dysautonomia characterized by persistent sympathetic hyperactivity and hyporeactivity to stress, supporting its classification as a sympathetically maintained neuropathic pain syndrome.
This review highlights the role of autonomic dysfunction and sympathetic hyperactivity in the pathophysiology of fibromyalgia.
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Highlights autonomic targets in fibromyalgia; hypothesis-generating and should not change practice without prospective trials.
Stress is a state of disharmony, or threatened homeostasis. A stressor could have a psychological origin or a biological origin. Societies have become more intricate with industrialization, and modern individuals try to adapt to the new defiance by forcing their stress response system. The main component of the stress response network is the autonomic nervous system. The present article reviews current knowledge on autonomic dysfunction in fibromyalgia. Sympathetic hyperactivity has been consistently described by diverse groups of investigators. Fibromyalgia is proposed to be a sympathetically maintained neuropathic pain syndrome, and genomic data support this contention. Autonomic dysfunction may also explain other fibromyalgia features not related to pain.
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Manuel Martínez‐Lavín (2007) conducted a review in Fibromyalgia. Autonomic nervous system dysfunction was evaluated. Fibromyalgia is associated with prominent dysautonomia characterized by persistent sympathetic hyperactivity and hyporeactivity to stress, supporting its classification as a sympathetically maintained neuropathic pain syndrome.
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