Further Studies of Platelet Reducing Substances in Splenic Extracts

Article1 January 1944FURTHER STUDIES OF PLATELET REDUCING SUBSTANCES IN SPLENIC EXTRACTSEUGENE P. CRONKITE, M.D.EUGENE P. CRONKITE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-1-52 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTroland and Lee, in 1938,1, 2 reported that acetone extracts of spleens from patients with "idiopathic" thrombopenic purpura produced a marked transient lowering of platelets when injected into rabbits. Some subsequent workers confirmed these results; others were unable to reproduce them.3, 4 Rose and Boyer,5 however, reported in 1940 from this clinic definite platelet lowering effects of spleen extracts from purpura cases and concluded that the results of Troland and Lee must be accepted. In 1940 Paul6 again reviewed the literature and made further experiments demonstrating a platelet depressing substance.The present report deals with further studies of the effect...Bibliography1. TROLANDLEE CEFC: A preliminary report on a platelet reducing substance in the spleen of thrombopenic purpura, Bull. Johns Hopkins Hosp., 1938, lii, 85. Google Scholar2. TROLANDLEE CEFC: Thrombocytopen. A substance in the extract from the spleen of patients with idiopathic thrombopenic purpura that reduces the number of blood platelets, Jr. Am. Med. Assoc., 1938, cxi, 221. CrossrefGoogle Scholar3. POHLEMEYER FJOO: Inability to demonstrate a platelet reducing substance in an acetone extract of the spleen from patients with idiopathic thrombopenic purpura, Jr. Clin. Invest., 1939, xviii, 537. CrossrefGoogle Scholar4. TOCANTINS LM: No platelet destroying action in extracts of the spleen and urine of patients with chronic thrombopenic purpura, Proc. Soc. Exper. Biol. and Med., 1939, xlii, 485. CrossrefGoogle Scholar5. ROSEBOYER HLB: Thrombocytopen. A confirmatory report, Jr. Clin. Invest., 1941, xx, 81. CrossrefGoogle Scholar6. PAUL JT: Effect of splenic extracts from cases of essential thrombopenic purpura upon platelets and hematopoietic organs of rabbits, Jr. Lab. and Clin. Med., 1942, xxvii, 754. Google Scholar7. TODDSANFORD : Clinical diagnosis, 1940, W. B. Saunders Co., Philadelphia. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication August 18, 1942.From the Department of Medicine, Stanford University School of Medicine, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byITP: a historical perspectiveThe Spleen and ThrombocytopeniaTurnover of Blood CellsPlatelet Survival and Platelet Production in Idiopathic Thrombocytopenic Purpura (ITP)Turnover in Cells and TissuesBIBLIOGRAPHYIndikationen zur Splenektomie bei BlutkrankheitenPhysiologische Beziehungen zwischen Milz und KnochenmarkBLOOD DYSCRASIAS SECONDARY TO GOLD: WITH A CASE OF HYPOPLASTIC ANEMIA CURED BY SPLENECTOMY*HENRY J. L. MARRIOTT, B.M. (Oxon.), H. RAYMOND PETERS, M.D., F.A.C.P.Recent Advances in HematologyPhysiology 1 January 1944Volume 20, Issue 1Page: 52-62KeywordsAcetonesPlateletsRabbitsSpleen Issue Published: 1 January 1944 PDF downloadLoading ...