Key result
Atrial fibrillation during sepsis hospitalizations was associated with a significantly higher all-cause in-hospital mortality rate (18.4%) compared to hospitalizations without atrial fibrillation (11.9%).
Why the study?
Large-scale contemporary data from the United States comparing outcomes among sepsis-related hospitalizations with versus without atrial fibrillation were limited.
Does the presence of atrial fibrillation increase in-hospital mortality and resource utilization in patients hospitalized with sepsis?
Cohort (n=5,808,166)
Yes
Does the presence of atrial fibrillation increase in-hospital mortality and resource utilization in patients hospitalized with sepsis?
Absolute Event Rate: 18.4% vs 11.9%
p-value: p=0.001
Atrial fibrillation is present in nearly 20% of sepsis hospitalizations and is associated with significantly higher in-hospital mortality, longer length of stay, and increased healthcare costs.
AF during sepsis may signal higher mortality risk but should not yet change practice; leaves open causality and need for intervention trials.
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Desai et al. (2019) conducted a cohort in Sepsis (n=5,808,166). Atrial fibrillation vs. Without atrial fibrillation was evaluated on All-cause in-hospital mortality (p=0.001). Atrial fibrillation during sepsis hospitalizations was associated with a significantly higher all-cause in-hospital mortality rate (18.4%) compared to hospitalizations without atrial fibrillation (11.9%).
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