Key result
Patients with major depressive disorder showed smaller left oxy-Hb changes during the verbal fluency task compared to healthy controls, which was positively correlated with suicide ideation.
Why the study?
Prefrontal asymmetry during cognitive tasks and its relation to suicide ideation had been less frequently examined in patients with major depressive disorder.
Does prefrontal asymmetry measured by fNIRS during cognitive tasks correlate with suicide ideation in patients with major depressive disorder?
Case-Control (n=106)
Does prefrontal asymmetry measured by fNIRS during cognitive tasks correlate with suicide ideation in patients with major depressive disorder?
fNIRS-measured prefrontal asymmetry during verbal fluency tasks may serve as a potential biomarker for assessing suicidal risk in patients with major depressive disorder.
Answers are grounded in this paper and cite their sources.
fNIRS prefrontal changes during verbal fluency may mark suicide ideation in MDD; leaves open prospective validation before clinical use.
Reduced oxygenation changes in the prefrontal cortex during cognitive tasks have been reported in major depressive disorder (MDD). However, prefrontal asymmetry during cognitive tasks and its relation to suicide ideations have been less frequently examined in patients with MDD. This study investigated prefrontal asymmetry and its moderating effect on the relationship between depression severity and suicidal ideation in MDD patients during cognitive tasks. Forty-two patients with MDD and 64 healthy controls (HCs) were assessed for changes in oxygenated and deoxygenated hemoglobin (Hb) in the prefrontal cortex using functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT), Stroop task, and two-back task. Depression, anxiety, and suicide ideation were measured through self-report questionnaires. Relatively smaller left oxy-Hb changes during VFT, but not during the Stroop or two-back tasks, were found in MDD patients compared with HCs. Furthermore, prefrontal asymmetry during VFT moderated the effect of depression severity on suicide ideation, and was significantly and positively correlated with suicide ideation in patients with MDD. Specifically, relatively greater left oxy-Hb changes were associated with greater suicide ideation. These findings suggest fNIRS-measured prefrontal asymmetry as a potential biomarker for MDD and for the assessment of suicidal risk in patients with MDD.
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Baik et al. (2019) conducted a case-control in Major Depressive Disorder (n=106). Major Depressive Disorder vs. Healthy controls was evaluated on Prefrontal asymmetry (oxy-Hb changes) during cognitive tasks and its relationship with suicide ideation. Patients with major depressive disorder showed smaller left oxy-Hb changes during the verbal fluency task compared to healthy controls, which was positively correlated with suicide ideation.
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