Key result
Major depressive disorder patients with suicidal ideation exhibited significantly higher cerebral blood flow in the bilateral precuneus and altered functional connectivity in the prefrontal-limbic system compared to those without suicidal ideation and healthy controls.
Why the study?
Relationships among cerebral blood flow, functional connectivity, and suicidal ideation in patients with major depressive disorder have remained elusive.
Population
175 individuals including 47 MDDNSI, 59 MDDSI, and 69 HC
Comparison
MDD with suicidal ideation vs MDD without suicidal ideation vs healthy controls
Authors
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May inform future suicide risk stratification in MDD; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=175)
No
p-value: p=<0.05
Abnormal functional connectivity mediates the association between regional cerebral blood flow and behavioral performances in MDD patients with suicidal ideation, highlighting the role of the precuneus gyrus, prefrontal-limbic system, and sensorimotor cortex.
Fan et al. (2022) conducted a cross-sectional in Major Depressive Disorder with or without suicidal ideation (n=175). Suicidal ideation vs. MDD without suicidal ideation and healthy controls was evaluated on Regional cerebral blood flow (CBF) and functional connectivity (FC) (p=<0.05). Major depressive disorder patients with suicidal ideation exhibited significantly higher cerebral blood flow in the bilateral precuneus and altered functional connectivity in the prefrontal-limbic system compared to those without suicidal ideation and healthy controls.
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