What question did this study set out to answer?

To examine the biological mechanisms underlying suicidal ideation in major depressive disorder through brain connectivity and immune transcriptomic profiles.

April 24, 2026Translational PsychiatryOpen Access

Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation

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Authors

MWMin Wang JWJinxue WeiSichuan University YYYushun YanSichuan University

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Implication

Exploratory analysis reveals altered brain connectivity and immune gene expression in MDD patients with suicidal ideation, suggesting links to biological mechanisms.

Key Points

To examine the biological mechanisms underlying suicidal ideation in major depressive disorder through brain connectivity and immune transcriptomic profiles.
Analyzed functional MRI and blood transcriptomic data from MDD patients with and without suicidal ideation and healthy controls.
Used network-based statistics to assess functional connectivity changes among groups, followed by graph-theoretical analysis.
Conducted differential module connectivity analyses to explore group differences in immune-related gene expression.
Significant brain network differences centered on the caudal temporal thalamus were found, with increased nodal efficiency in MDD_SI and MDD_nSI groups.
Immune transcriptomic modules in MDD_SI showed enrichment in antiviral responses and energy dysregulation pathways.
Correlation analyses indicated connections between brain connectivity metrics and transcriptomic alterations specifically in the MDD_SI group.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69eb084f553a5433e34b35c8 https://doi.org/10.1038/s41398-026-04047-w

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Implication

Exploratory analysis reveals altered brain connectivity and immune gene expression in MDD patients with suicidal ideation, suggesting links to biological mechanisms.

Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation

Discussion

Member takes

Implication

Key Points

Cite This Study

Thalamocortical functional connectivity alterations and peripheral immune transcriptomic dysregulation in major depressive disorder patients with suicidal ideation

Discussion

Member takes

Implication

Key Points

Cite This Study

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