What type of study is this?

This is a TMS-EEG study (also classified as: Observational).

September 10, 2025Translational PsychiatryOpen Access

Heightened effective connectivity of DLPFC-mPFC and DLPFC-ACC circuits in major depressive disorder with suicidal ideation: evidence from a TMS-EEG study

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TMS-EEG analysis demonstrates increased effective connectivity in DLPFC-mPFC and DLPFC-ACC circuits for subjects with suicidal ideation.

MDD patients with suicidal ideation show enhanced effective connectivity between the DLPFC and key regions.
Increased N100 amplitudes were observed in the SI group compared to the NSI and control groups.
Significant associations were found linking effective connectivity patterns to suicidal ideation presence.
Altered cortical inhibition was noted in MDD patients, contributing to their suicidal ideation.

Chen et al. (2025) studied this question.

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