Key result
Oral controlled release oxycodone provided similar post-operative pain relief to controlled release tramadol but resulted in significantly less nausea and emesis (p=0.011, p=0.013).
Why the study?
Does oral controlled release oxycodone improve post-operative pain and reduce side effects compared to oral controlled release tramadol in patients scheduled for orthopedic surgery?
RCT (n=57)
Double-blind
randomized
Does oral controlled release oxycodone improve post-operative pain and reduce side effects compared to oral controlled release tramadol in patients scheduled for orthopedic surgery?
Controlled release oxycodone provides similar pain relief to controlled release tramadol but with significantly less nausea and emesis following orthopedic surgery.
No takes yet. Share an insight, caveat, or question.
Supports preferring controlled-release oxycodone over tramadol after orthopedic surgery; extends RCT evidence guiding opioid selection by tolerability.
Wirz et al. (2005) conducted an RCT in Post-operative pain following orthopedic surgery (n=57). Oral controlled release oxycodone vs. Oral controlled release tramadol was evaluated on Pain at rest and during exercise, vital signs, and side effects. Oral controlled release oxycodone provided similar post-operative pain relief to controlled release tramadol but resulted in significantly less nausea and emesis (p=0.011, p=0.013).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: