Key result
Renal denervation ameliorates inflammation in pyelonephritis but may exacerbate LPS- and antibody-induced acute kidney injury due to persistent glomerular hyperfiltration in animal models.
Why the study?
Does renal denervation improve renal inflammation and injury in mice with nephritis and pyelonephritis?
Does renal denervation improve renal inflammation and injury in mice with nephritis and pyelonephritis?
This editorial highlights the complex, context-dependent effects of renal denervation on kidney inflammation, suggesting that pharmacological targeting of sympathetic pathways may be preferable to permanent ablation.
Sympathetic nerves innervate the kidney and help regulate glomerular perfusion and filtration, and after renal denervation, altered regulation may affect the course of kidney disease. However, our understanding of denervation’s effects on kidney function in humans is incomplete. The autonomous
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A 2021 study conducted an editorial in Nephritis and Chronic Kidney Disease. Renal denervation was evaluated. Renal denervation ameliorates inflammation in pyelonephritis but may exacerbate LPS- and antibody-induced acute kidney injury due to persistent glomerular hyperfiltration in animal models.
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