A high performance liquid chromatographic method is described for the determination of diclofenac in human plasma, using naproxen as the internal standard. This method is simple, rapid and cost-effective. Zinc sulphate (5%) and methanol were used for extraction. Prepared samples were analysed on a nucleosil C18 column using a 35:65 acetonitrile-water phosphate buffered mobile phase (pH 2.8) and ultraviolet detection at 280 nm. The assay was linear in the range 30 ng/ml to 2 μg/ml, with recovery of extraction ranging from 82 to 97% and a detection limit of 30 ng/ml.
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Mason et al. (1995) studied this question.
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