Key result
In isolated aged rat hearts, single-dose del Nido cardioplegia resulted in superior functional recovery at 60 minutes compared to multi-dose cardioplegia (71 vs 43 ml*mmHg*g(-1), p=0.0175).
Why the study?
Does single-dose del Nido cardioplegia improve functional recovery compared to multi-dose del Nido cardioplegia in isolated senescent rat hearts?
Does single-dose del Nido cardioplegia improve functional recovery compared to multi-dose del Nido cardioplegia in isolated senescent rat hearts?
Absolute Event Rate: 71% vs 43%
p-value: p=0.0175
In aged rat hearts, single-dose del Nido cardioplegia provides superior functional recovery compared to multi-dose delivery.
Hypothesis-generating for single-dose del Nido in aged hearts; human trials needed before clinical consideration.
BACKGROUND: Aged hearts are particularly vulnerable to reperfusion injury. We recently showed that single-dose del Nido cardioplegia was superior to 'standard' multi-dose 4:1 blood cardioplegia in aged rat hearts. This study seeks to determine if multi-dose del Nido cardioplegia offers additional benefits over single-dose del Nido cardioplegia. METHODS: Functional recovery after 60 min of cardioplegic arrest was assessed in isolated, working, senescent rat hearts. Single-dose del Nido cardioplegia (n=14) was compared to multi-dose del Nido cardioplegia (n=12) delivered every 20 min. RESULTS: Troponin release during reperfusion was similar in the single (0.263 ± 0.056 ng/ml) and multi-dose groups (0.261 ± 0.055 ng/ml). Although functional recovery was similar early after reperfusion (stroke work 91 ± 6 ml*mmHg*g(-1) vs. 91 ± 8 ml*mmHg*g(-1) for single- vs. multi-dose), it declined over time in the multi-dose group (71 ± 9 vs. 43 ± 9 ml*mmHg*g(-1) at 60 min, p=0.0175) CONCLUSIONS: In aged rat hearts, a single-dose del Nido cardioplegia strategy results in superior functional recovery compared to a multi-dose del Nido cardioplegia strategy.
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Govindapillai et al. (2015) studied Reperfusion injury during cardiac surgery (n=26). Single-dose del Nido cardioplegia vs. Multi-dose del Nido cardioplegia (delivered every 20 min) was evaluated on Functional recovery (stroke work) at 60 min after reperfusion (p=0.0175). In isolated aged rat hearts, single-dose del Nido cardioplegia resulted in superior functional recovery at 60 minutes compared to multi-dose cardioplegia (71 vs 43 ml*mmHg*g(-1), p=0.0175).
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