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A simple, sensitive, and rapid RP-HPLC method was successfully developed and validated for the simultaneous estimation of Sumatriptan succinate and Naproxen sodium in bulk and tablet dosage forms.
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A simple, accurate, and precise RP-HPLC method was developed and validated for the simultaneous estimation of Sumatriptan succinate and Naproxen sodium in pharmaceutical formulations.
A simple, sensitive and rapid reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Sumatriptan succinate and Naproxen sodium. C18 column (250x 4.6 mm, 5μ) was used with a mobile phase containing a mixture Acetonitrile: Methanol: phosphate buffer in the ratio of 50:10:40 at pH 6.The flow rate was 1.0ml/min and effluents were monitored at 229 nm at flow rate of 1 ml/min. The retention time was found to be 4.037 min for Naproxen sodium and 2.813 min for Sumatriptan Succinate. Calibration curve was plotted with a range from 1-5μg/ml for Sumatriptan succinate and Naproxen sodium. The assay was validated for parameters like accuracy, precision, robustness and system suitability parameters. The proposed method can be useful in the routine analysis for determination on Sumatriptan succinate and Naproxen sodium.
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Gondalia et al. (2013) studied this question. RP-HPLC method was evaluated on Simultaneous estimation of Sumatriptan succinate and Naproxen sodium. A simple, sensitive, and rapid RP-HPLC method was successfully developed and validated for the simultaneous estimation of Sumatriptan succinate and Naproxen sodium in bulk and tablet dosage forms.
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