Key result
Laparotomy in patients with secondary peritonitis did not significantly increase systemic inflammatory mediators, but significantly decreased platelet count (P=0.001).
Why the study?
Does laparotomy increase the systemic inflammatory response in patients with secondary peritonitis?
Population
5 patients suffering from secondary peritonitis, median age 84 years, male to female ratio 2:3.
Design
Cohort
Follow-up
perioperatively
Authors
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Laparotomy may not heighten systemic inflammation in secondary peritonitis; challenges animal model data but leaves open platelet effects and needs prospective confirmation.
Observational (n=5)
Does laparotomy increase the systemic inflammatory response in patients with secondary peritonitis?
p-value: p=0.001
Laparotomy in human patients with secondary peritonitis did not significantly increase the systemic inflammatory response, contrary to findings in animal models.
Mahamid et al. (2014) conducted an observational in Secondary peritonitis (n=5). Laparotomy was evaluated on Systemic inflammatory response (levels of white blood cells, C-reactive protein, platelets, interleukin-six, and tumor necrosis factor-alpha) (p=0.001). Laparotomy in patients with secondary peritonitis did not significantly increase systemic inflammatory mediators, but significantly decreased platelet count (P=0.001).
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