Adrenal response to corticotropin administration was studied in six Holstein heifers injected intramuscularly once with 250 IU of corticotropin. Blood was sampled at 0, .25, .50, .75, 1, 2, 4, 8, and 24 hr after injection and was analyzed for plasma corticoids, total leukocytes, differential ]eukocytes, serum sodium, potassium, calicum, magnesium, and chloride. Plasma corticoids rose within 15 min and were associated with leukocytosis, lymphophenia, eosinopenia, hypernatremia, hyperchloremia, hypokalemia, hypomagnesemia, and hypocalcemia. Time-response and duration of these changes were compared as an index of adrenal activity.
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Wegner et al. (1972) studied this question.
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