Bone Marrow Depression Successfully Treated With Hydrocortisone and Corticotropin (Acth)

Case Reports1 February 1957BONE MARROW DEPRESSION SUCCESSFULLY TREATED WITH HYDROCORTISONE AND CORTICOTROPIN (ACTH)JOHN F. MURRAY, M.D., S. FRED RABINER, M.D., BERNARD KABAKOW, M.D.JOHN F. MURRAY, M.D.Search for more papers by this author, S. FRED RABINER, M.D.Search for more papers by this author, BERNARD KABAKOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-2-387 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCortisone, hydrocortisone, and adrencorticotropic hormone (ACTH) have been employed therapeutically in a variety of blood dyscrasias.1 These compounds have been found particularly effective in thrombocytopenic purpura,2 acquired hemolytic anemias3 and, to a lesser extent, in acute leukemias.4 Recently several reports have suggested that cortisone and ACTH are useful, and may perhaps be life-saving, in the treatment of drug-induced agranulocytosis.5-9The following is a report of a patient with marked bone marrow depression, possibly secondary to propylthiouracil administration, who showed an initial response to intravenous hydrocortisone and was subsequently successfully treated with ACTH.CASE REPORTA 36 year old white unmarried...Bibliography1. Second Report to the Medical Research Council by the Panel on the Haematological Applications of ACTH and Cortisone; Treatment of Blood Disorders with ACTH and Cortisone, Brit. M. J. 2: 1400-1401, 1953. CrossrefMedlineGoogle Scholar2. Lozner EL: Differential diagnosis, pathogenesis and treatment of the thrombocytopenic purpuras, Am. J. Med. 14: 459-468, 1953. CrossrefMedlineGoogle Scholar3. SacksWorkmanJahn MSJBEF: Diagnosis and treatment of acquired hemolytic anemia, J.A.M.A. 150: 1556-1559, 1952. CrossrefMedlineGoogle Scholar4. FessasWintrobeThompsonCartwright PMMRBGE: Treatment of acute leukemia with cortisone and corticotropin, Arch. Int. Med. 94: 384-401, 1954. CrossrefGoogle Scholar5. CaldwellAdamsAndersonDick ALJWJFAA: Agranulocytosis treated with cortisone, Canad. M. A. J. 62: 506-507, 1950. MedlineGoogle Scholar6. McMillin JS: Successful use of ACTH in the treatment of agranulocytosis due to sulfadiazine, Am. J. M. Sc. 222: 392-395, 1951. CrossrefMedlineGoogle Scholar7. Virkkunen M: Corticotropin and cortisone in the treatment of agranulocytosis and thrombocytopenic purpura, Arch. Int. Med. 90: 580-586, 1952. CrossrefGoogle Scholar8. Fuld H: Use of ACTH in agranulocytosis, Brit. M. J. 2: 1133-1134, 1952. CrossrefMedlineGoogle Scholar9. LevineRosenberg BDV: Aplastic anemia during the treatment of hyperthyroidism with Tapazole, Ann. Int. Med. 41: 844-848, 1954. LinkGoogle Scholar10. DarlingParkerJackson RCFH: The pathological changes in the bone marrow in agranulocytosis, Am. J. Path. 12: 1-12, 1936. MedlineGoogle Scholar11. RhoadsMiller CPDK: Histology of the bone marrow in aplastic anemia, Arch. Path. 26: 648, 1938. Google Scholar12. HillsForshamFinch AGPHCA: Changes in circulating leukocytes induced by the administration of pituitary adrenocorticotrophic hormone (ACTH) in man, Blood 3: 755-768, 1948. CrossrefMedlineGoogle Scholar13. MoeschlinWagner SK: Agranulocytosis due to the occurrence of leukocyte-agglutinins (Pyramidon and cold agglutinins), Acta haemat. 8: 29-41, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 14, 1955.From the Division of Hematology, Department of Medicine, State University of New York College of Medicine at New York City, Brooklyn, N. Y.Requests for reprints should be addressed to Bernard Kabakow, M.D., Montefiore Hospital, 210th Street and Bainbridge Avenue, New York 67, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCortisone and its Analogues in Alimentary DisordersCortisone and its Analogues in HaematologyACTH and Adrenocorticosteroids as Therapeutic Adjuncts in Infectious Diseases 1 February 1957Volume 46, Issue 2Page: 387-391KeywordsAdrenocorticotropic hormoneBloodBone marrowDrug administrationDrugsHematology and oncologyHormonesSteroid therapy ePublished: 1 December 2008 Issue Published: 1 February 1957 PDF downloadLoading ...