Key result
In 82 postmortem cases of myocarditis, myocyte necrosis was found in 98% of cases and mononuclear inflammation (lymphocytes) was the predominant tissue response, seen in 73% of cases.
Why the study?
Myocarditis poses a diagnostic challenge in sudden death due to lack of specific symptoms and potential mimicry of myocardial infarction, making autopsy histopathology essential.
Observational (n=82)
No
In postmortem specimens of sudden death cases, myocarditis predominantly affects young males and is characterized by mononuclear inflammation and myocyte necrosis.
Postmortem myocarditis histology warrants diagnostic caution; leaves open prospective validation of mononuclear predominance in clinical cases.
In cases of sudden death, myocarditis is not an unusual finding especially when communicable diseases of viral origin are on the rise. Detection of myocarditis poises a diagnostic challenge to clinicians due to the absence of specific symptoms and there is a possibility of this being masqueraded as myocardial infarction. Examination of autopsy specimens are of utmost importance to detect the underlying etiology. For diagnosis of myocarditis histopathological examination of cardiac tissue is the gold standard. This is carried out based on Dallas criteria. Aim-This study was done to assess the, gross and histopathology findings in myocarditis in post mortem specimens in a tertiary care hospital in Kerala over a span of 4 years.
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Joseph et al. (2020) conducted an observational in Myocarditis (n=82). Myocarditis was evaluated on Histomorphological patterns including inflammation and myocyte necrosis. In 82 postmortem cases of myocarditis, myocyte necrosis was found in 98% of cases and mononuclear inflammation (lymphocytes) was the predominant tissue response, seen in 73% of cases.
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