Population
Rats with and without subfornical organ (SFO) lesions
Comparison
Captopril given acutely following 24-h water… vs Control rats receiving captopril, and rats not…
Design
Preclinical
Follow-up
acutely or chronically over several days
Authors
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No immediate clinical implications; extends evidence for distinct SFO-dependent pathways in water versus NaCl intake.
The subfornical organ is necessary for captopril-enhanced water intake but not NaCl intake in rats, suggesting distinct neurological mechanisms for fluid ingestion.
Thunhorst et al. (1987) studied this question.
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