Why the study?
Does intravenous edathamil disodium-induced hypocalcemia alter electrocardiographic parameters in normal subjects?
Does intravenous edathamil disodium-induced hypocalcemia alter electrocardiographic parameters in normal subjects?
Acute hypocalcemia induced by edathamil disodium in normal subjects prolongs RS-T and Q-T intervals without altering spatial vectors or causing T wave or RS-T segment abnormalities.
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Induced hypocalcemia alters QT-RS-T intervals in normals; leaves open whether findings guide monitoring or risk stratification in patients.
In the past, it has not been possible to study the electrocardiographic effects of hypocalcemia in normal subjects. Edathamil disodium is a powerful chelating agent with a strong affinity for ionic calcium when given intravenously. This agent was used to produce hypocalcemia in normal subjects so that electrocardiographic effects could be studied. The major changes produced in the electrocardiogram with the induction of hypocalcemia were shortening of the R-R interval, prolongation of the RS-T and Q-T intervals, all of which were proportional to the degree of hypocalcemia. No change in the spatial P, QRS and T vectors, no T wave flattening or inversion and no elevation or depression of the RS-T segment appeared with hypocalcemia.
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Bechtel et al. (1956) studied this question.
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