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A bleomycin mixture which contained A2 as the main component and B2 as the second component was tritiated. The 3H-bleomycin thus prepared was subcutaneously injected to mice and the distribution of the bleomycin among organs of mice was determined. The results indicated a high concentration in skin and peritoneum. The concentrations determined by radioactivity were higher than those determined by the antibacterial activity suggesting that tissue contains some substance which reduces the bacterial activity against B. subtilis or inactivates the bleomycin.
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UMEZAWA et al. (1968) studied this question.
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