Key result
Analysis of 131 G1 rotavirus VP7 gene sequences identified three novel intragenic recombinant rotaviruses (2.3%), demonstrating the existence of interlineage and intersublineage recombination.
Alerts to emerging rotavirus diversity; extends recombination evidence but leaves open clinical and vaccine implications.
The G1 rotavirus is the most widespread genotype causing acute gastroenteritis in children. In an attempt to investigate the occurrence of intragenic recombination, 131 complete coding region sequences of VP7 genes of the G1 rotaviruses in GenBank were examined. Three hitherto-unreported intragenic recombinant rotaviruses were identified. It was noteworthy that two different types (interlineage and intersublineage) of intragenic recombination in rotaviruses were also found. This is the first report to demonstrate the existence of intragenic recombinations between interlineage and intersublineage in G1 rotaviruses.
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Phan et al. (2007) studied G1 rotavirus (n=131). G1 rotavirus VP7 genes was evaluated on Occurrence of intragenic recombination. Analysis of 131 G1 rotavirus VP7 gene sequences identified three novel intragenic recombinant rotaviruses (2.3%), demonstrating the existence of interlineage and intersublineage recombination.
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