Key result
Perinatal asphyxia was significantly associated with elevated cardiac troponin-T levels (66.7% vs 0%), and clinical signs such as pallor strongly predicted myocardial injury (OR 107.67).
Why the study?
Do specific clinical signs correlate with elevated cardiac troponin T levels in term neonates with perinatal asphyxia?
Case-Control (n=60)
Yes
Do specific clinical signs correlate with elevated cardiac troponin T levels in term neonates with perinatal asphyxia?
Simple clinical signs such as pallor, cyanosis, tachycardia, and depressed sensorium can serve as reliable indicators of myocardial injury in asphyxiated neonates in resource-limited settings.
Clinical signs like pallor may flag myocardial injury in asphyxiated neonates; hypothesis-generating and requires prospective validation.
Introduction: Resource limitation in developing countries may preclude access to cardiac troponin-T assay thereby necessitating reliance on clinical judgment for identification of hypoxic myocardial cellular injury.Objectives: To relate selected clinical signs with elevated serum cardiactroponin-T in asphyxiated term neonates.Methods: Asphyxia was identified by low umbilical arterial blood pH . 7.20 and low five minute Apgar score . 6 while controls were term, non.asphyxiated neonates. All babies were examined for heart rate,heart rhythm irregularities, peripheral pulse volume, respiratory rate,pallor, cyanosis, heart murmur and sensorium.Results: Thirty term, asphyxiated neonates and their matched controlswere studied. Central cyanosis, reduced pulse volume, pallor, depressedsensorium; tachycardia and tachypnea were all associated with increased odds ratios for abnormal cardiac troponin.T levels.Conclusion: Clinicians working in resource.limited health facilitiesshould have a high index of suspicion for myocardial cellular injurywhen these signs are elicited.
No takes yet. Share an insight, caveat, or question.
Uzodimma et al. (2013) conducted a case-control in Perinatal asphyxia (n=60). Perinatal asphyxia vs. Non-asphyxiated term neonates was evaluated on Elevated serum cardiac troponin-T (> 0.10 ng/ml) (p=<0.001). Perinatal asphyxia was significantly associated with elevated cardiac troponin-T levels (66.7% vs 0%), and clinical signs such as pallor strongly predicted myocardial injury (OR 107.67).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: