Key result
Cardiac troponin-I levels were significantly higher in newborns with perinatal asphyxia who survived (0.082 µg/L) or died (0.425 µg/L) compared to healthy controls (0.0186 µg/L).
Why the study?
Does cardiac troponin-I level correlate with outcomes and mortality in critically ill newborns with perinatal asphyxia?
Observational (n=78)
Does cardiac troponin-I level correlate with outcomes and mortality in critically ill newborns with perinatal asphyxia?
Absolute Event Rate: 0.082% vs 0.0186%
High cardiac troponin-I levels measured 24-48 hours after delivery correlate with mortality and the need for cardio-respiratory support in newborns with perinatal asphyxia.
Elevated troponin-I may indicate mortality risk in perinatal asphyxia; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND/AIM: Myocardial cell lesion in newborns may be clinically occult. In recent years there has been shown growing interest in the use of cardiac troponin-I (cTnI) in relation to perinatal asphyxia and hypoxic myocardial lesion. The aim of this study was to determine a relationship between high cTnI levels and outcome in critically ill newborns with perinatal asphyxia. METHODS: In this study 78 patients were divided into three groups. The group I included 39 newborns (15 term and 24 preterm) with perinatal asphyxia, with no deaths, only full or partial (with some neurological sequels) recovery. The group II included 10 newborns (6 preterm and 4 term), with perinatal asphyxia who died, with critical cardio-respiratory problems and multiorgan dysfunction. The group III included 29 healthy term newborns. A level of cTnI in all three groups was measured within 24-48 hours after delivery. RESULTS: A statistically significant higher value of cTnI (0.082 microg/l +/- 0.166) was found in group I than in the group III (healthy newborns). In the group I, 21/39 newborns required respiratory and 16/39 required pressure support. In the group II, the largest average value of cTnI of 0.425 +/- 0.307 was found. All of the newborns in the group II required respiratory and pressure support. In the group III the lowest average value of cTnI (0.0186 microg/L +/- 0.0286) was found. CONCLUSIONS: High cTnI levels could be used as markers of perinatal asphyxia and even as predictors of future outcomes and/or mortality.
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Simović et al. (2009) conducted an observational in Perinatal asphyxia (n=78). Perinatal asphyxia vs. Healthy term newborns was evaluated on Cardiac troponin-I (cTnI) level. Cardiac troponin-I levels were significantly higher in newborns with perinatal asphyxia who survived (0.082 µg/L) or died (0.425 µg/L) compared to healthy controls (0.0186 µg/L).
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