Key result
Perinatal asphyxia was associated with significantly higher median cardiac troponin I concentrations compared to healthy controls (0.36 vs 0.04 microg/l; p<0.01).
Why the study?
Does perinatal asphyxia increase serum concentrations of cardiac troponin I in neonates compared to healthy controls?
Case-Control (n=52)
Does perinatal asphyxia increase serum concentrations of cardiac troponin I in neonates compared to healthy controls?
Cardiac troponin I is significantly elevated in asphyxiated neonates, suggesting myocardial damage, but does not correlate with traditional markers of asphyxia.
Suggests myocardial injury in asphyxiated neonates; hypothesis-generating for cTnI utility, needs prospective validation.
BACKGROUND: Cardiac troponins T (cTnT) and I (cTnI) are well-established markers in detecting myocardial ischemic damage in adults. Perinatal asphyxia is associated with cardiac dysfunction. OBJECTIVES: To evaluate serum concentrations of cTnI in asphyxiated neonates and to investigate whether cTnI is correlated with the traditional markers of asphyxia. METHODS: Blood samples were collected from 13 asphyxiated neonates (umbilical artery pH<7.18 and either a 1-min Apgar score<4 or a 5-min Apgar score<7) and 39 controls. Data on gestation, birth weight, sex, Apgar scores, mode of delivery, umbilical pH, creatinine, serum activity of aspartate and alanine aminotransferase, and QTc interval were investigated. RESULTS: Median (range) cTnI concentrations were significantly higher in asphyxiated neonates with respect to healthy infants: 0.36 microg/l (0.05-11) versus 0.04 microg/l (0.04-0.06); p<0.01. In asphyxiated babies, no statistically significant correlations were found between concentrations of cTnI and the other markers of asphyxia. CONCLUSIONS: In asphyxiated neonates, cTnI concentrations are higher with respect to healthy infants, suggesting the presence of myocardial damage in this group of high-risk patients. cTnI does not correlate with the traditional markers of asphyxia.
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Trevisanuto et al. (2006) conducted a case-control in Perinatal asphyxia (n=52). Perinatal asphyxia vs. Healthy controls was evaluated on Serum concentrations of cardiac troponin I (cTnI) (p=<0.01). Perinatal asphyxia was associated with significantly higher median cardiac troponin I concentrations compared to healthy controls (0.36 vs 0.04 microg/l; p<0.01).
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