Cardiac troponin I may remain elevated for up to 3 weeks following mild perinatal asphyxia even with normal echocardiographic cardiac function.
cTnI may remain elevated weeks after mild perinatal asphyxia despite normal function; case report leaves open need for validated neonatal reference ranges.
Cardiac troponins can be useful in monitoring cardiac injury following perinatal distress. We report here an increase of cardiac troponin I (cTnI) to 2.84 microg/l at 3 weeks (age-related median: 0.07 microg/l) followed by normalization in a newborn with an uneventful clinical course after resuscitation at birth. Serial echocardiographs showed normal cardiac function. Such a time course of cTnI, not previously reported, could be due to either a greater sensitivity of biochemical markers than of instrumental tools or birth asphyxia. Larger studies are needed
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Cavalli et al. (2005) studied this question.
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