What question did this study set out to answer?

To measure circulating plasma concentrations of lignans and isoflavonic phytoestrogens in postmenopausal women following targeted dietary supplementation.

August 1, 1994Journal of Endocrinology

Determination of lignans and isoflavonoids in human female plasma following dietary supplementation

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Authors

MMMichael S. MortonAstraZeneca (United Kingdom)GWGisela WilcoxSalford Royal NHS Foundation Trust MWMark L. WahlqvistNational Health Research Institutes

Discussion

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Implication

Dietary intervention study reveals significant plasma increases in lignans and isoflavonoids among postmenopausal women, suggesting a protective role against hormone-dependent cancers.

Key Points

To measure circulating plasma concentrations of lignans and isoflavonic phytoestrogens in postmenopausal women following targeted dietary supplementation.
Supplemented the traditional diet of postmenopausal Australian women with linseed, soya flour, or clover sprouts.
Quantified plasma concentrations via enzymatic hydrolysis and ion-exchange chromatography followed by gas chromatography-mass spectrometry.
Linseed supplementation increased combined plasma enterolactone and enterodiol concentrations to 500 ng/ml.
Soya flour or clover sprout supplementation produced peak plasma concentrations of daidzein (312 ng/ml), genistein (148 ng/ml), and equol (43 ng/ml).
Not all women exhibited the metabolic capacity to synthesize equol from daidzein.

Cite This Study

Morton et al. (1994) studied this question.

synapsesocial.com/papers/6a8c33b95ef9ff12d78963ec https://doi.org/10.1677/joe.0.1420251

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August 1, 1994Journal of Endocrinology

Determination of lignans and isoflavonoids in human female plasma following dietary supplementation

View Full Paper

Ask AI

Bookmark

Authors

MMMichael S. MortonAstraZeneca (United Kingdom)GWGisela WilcoxSalford Royal NHS Foundation Trust MWMark L. WahlqvistNational Health Research Institutes

Discussion

Member takes

Implication

Dietary intervention study reveals significant plasma increases in lignans and isoflavonoids among postmenopausal women, suggesting a protective role against hormone-dependent cancers.

Key Points

To measure circulating plasma concentrations of lignans and isoflavonic phytoestrogens in postmenopausal women following targeted dietary supplementation.
Supplemented the traditional diet of postmenopausal Australian women with linseed, soya flour, or clover sprouts.
Quantified plasma concentrations via enzymatic hydrolysis and ion-exchange chromatography followed by gas chromatography-mass spectrometry.
Linseed supplementation increased combined plasma enterolactone and enterodiol concentrations to 500 ng/ml.
Soya flour or clover sprout supplementation produced peak plasma concentrations of daidzein (312 ng/ml), genistein (148 ng/ml), and equol (43 ng/ml).
Not all women exhibited the metabolic capacity to synthesize equol from daidzein.

Cite This Study

Morton et al. (1994) studied this question.

synapsesocial.com/papers/6a8c33b95ef9ff12d78963ec https://doi.org/10.1677/joe.0.1420251

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