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This review highlights the emerging treatment strategies for pulmonary hypertension secondary to left heart disease, noting the critical gap of large randomized controlled trials in this high-risk population.
At least two thirds of patients with chronic severe left heart disease have associated pulmonary hypertension, and mortality associated with biventricular failure is >two-fold higher compared with isolated left ventricular failure. This review considers and discusses emerging concepts and strategies from recent studies of specific treatments in populations with pulmonary hypertension complicating overt left ventricular dysfunction. While the results reported in the studies considered are encouraging, to date there are no large randomised studies of specific treatments in populations with pulmonary hypertension complicating overt left ventricular dysfunction.
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O’Callaghan et al. (2008) conducted a review in Pulmonary hypertension complicating overt left ventricular dysfunction. Specific treatments for pulmonary hypertension was evaluated.
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