Dermatitis, Hepatitis and Nephritis Due to Phenindione (Phenylindandione)

Case Reports1 March 1960DERMATITIS, HEPATITIS AND NEPHRITIS DUE TO PHENINDIONE (PHENYLINDANDIONE)R. H. BROOKS, M.D., H. B. CALLEJA, M.D.R. H. BROOKS, M.D.Search for more papers by this author, H. B. CALLEJA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-706 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe last decade has seen universal acceptance of anticoagulant therapy in thromboembolic diseases. In the treatment of individual cases, however, particularly those of acute coronary occlusion, opinion varies as to which cases should receive anticoagulants, and how long therapy should be continued. In addition, hemorrhage is generally accepted as a calculated risk directly attributable to the very nature of the therapy, regardless of the type and kind of anticoagulant used. Indeed, fatal hemorrhagic complications have occurred. Cautious, close supervision of the patient, better knowledge of the type of drug used, and due respect for established contraindications must be emphasized if...Bibliography1. MakousVander Veer NJB: Severe drug sensitivity reaction to phenindione (phenylindandione), J. A. M. A. 155: 729, 1954. MedlineGoogle Scholar2. Kirkeby K: Agranulocytosis following treatment with phenylindandione, Lancet 2: 580, 1954. CrossrefGoogle Scholar3. SoulierGueguen JPJ: Action hypoprothrombinemiante (anti-K) de la phenylindanedione etudiee experimentalement chez le lapin: Son application chez l'homme, Compt. rend. Soc. de biol. 141: 1007, 1947. Google Scholar4. BurnsDesmond CFB: Sensitivity to Dindevan (phenylindandione). Report of a case with review of the literature, New Zealand M. J. 57: 283, 1958. MedlineGoogle Scholar5. EastBeamish ENRE: Severe sensitivity reaction (hepatitis, dermatitis, and pyrexia) attributable to phenylindanedione, Canad. M. A. J. 77: 1028, 1957. MedlineGoogle Scholar6. Johman L: Sensitivity to phenindione: report of a case, Scottish M. J. 2: 330, 1957. CrossrefMedlineGoogle Scholar7. BrownMacMillan KWRL: The choice of an anticoagulant, Am. J. M. Sc. 227: 526, 1954. CrossrefMedlineGoogle Scholar8. CoonDuffHodgsonDennis WWIFPEEW: Therapeutic evaluation of a new anticoagulant, phenylindandione, Ann. Surg. 138: 467, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication October 30, 1959.From the White Cross Hospital, Columbus, Ohio.†Fellow of the Central Ohio Heart Association in Clinical Cardiology, White Cross Hospital.Requests for reprints should be addressed to Richard H. Brooks, M.D., 4345 North High Street, Columbus 14, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcetylsalicylic Acid 50-78-2Adverse Effects of Drugs on the LiverOrale AntikoagulantienSENSITIVITY TO PHENINDIONE (“DINDEVAN”)ANTICOAGULANTS-AN EMPIRICAL EVALUATION*Nebenwirkungen der Therapie mit AnticoagulantienEFFECT OF ANDROGENS ON NUCLEI OF NEUTROPHIL LEUCOCYTESNEPHROPATHY DURING PHENINDIONE THERAPY 1 March 1960Volume 52, Issue 3Page: 706-710KeywordsAdrenocorticotropic hormoneAnticoagulant therapyAnticoagulantsDrugsEczemaHeartHemorrhageHepatitisNephritis Issue Published: 1 March 1960 PDF downloadLoading ...