Key result
The G-allele of SNP rs10757278 at the CDKN2A/CDKN2B locus was associated with an increased risk of incident stroke in hypertensive patients (HR 1.34; 95% CI 1.09-1.65; P=0.006).
Why the study?
Does genetic variation at the CDKN2A/CDKN2B locus (SNPs rs2383207 and rs10757278) predict stroke and coronary events in patients with hypertension?
Population
5,262 patients with hypertension who provided DNA from the Nordic Diltiazem study (original n=10,881)
Comparison
Presence of G-allele of SNPs rs2383207 and… vs Absence of the risk allele (non-carriers)
Design
Cohort
Authors
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Does not support genotyping for stroke risk in hypertension; extends 9p21 associations but remains hypothesis-generating.
Observational (n=5,262)
Does genetic variation at the CDKN2A/CDKN2B locus (SNPs rs2383207 and rs10757278) predict stroke and coronary events in patients with hypertension?
Hazard Ratio: 1.34 (95% CI 1.09–1.65)
p-value: p=0.006
Genetic variation at the CDKN2A/CDKN2B locus on chromosome 9p21 independently predicts stroke and coronary events in hypertensive patients, suggesting a shared disease mechanism.
Wahlstrand et al. (2009) conducted an observational in Hypertension (n=5,262). CDKN2A/CDKN2B locus SNPs (rs2383207 and rs10757278) G-allele vs. Non-risk allele carriers was evaluated on Incident stroke (HR 1.34, 95% CI 1.09-1.65, p=0.006). The G-allele of SNP rs10757278 at the CDKN2A/CDKN2B locus was associated with an increased risk of incident stroke in hypertensive patients (HR 1.34; 95% CI 1.09-1.65; P=0.006).
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