Why the study?
Does low molecular weight heparin improve treatment compared to continuous intravenous unfractionated heparin in patients with deep vein thrombosis?
Does low molecular weight heparin improve treatment compared to continuous intravenous unfractionated heparin in patients with deep vein thrombosis?
Low molecular weight heparins overcome the pharmacokinetic limitations of unfractionated heparin, allowing for predictable anticoagulation without laboratory monitoring.
Answers are grounded in this paper and cite their sources.
May enable outpatient DVT management without monitoring; leaves open comparative effectiveness versus unfractionated heparin.
Each year, deep vein thrombosis (DVT) affects two million Americans, and pulmonary embolism (PE) affects 600,000. Traditional treatment requires hospitalization to receive continuous intravenous unfractionated heparin (UFH), which has substantial pharmacokinetic limitations. Low molecular weight heparins have overcome many of these limitations, resulting in a predictable anticoagulant response without the need for laboratory monitoring or dosage adjustment.
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Nadeau et al. (2003) studied this question.
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