Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

Acute myeloid leukemia (AML) is a heterogeneous disease with diverse genetic abnormalities and variable response to treatment. In the last decade the diverse genetic abnormalities have refined risk-stratification of AML.[1][1] Recently, mutations in the Casitas B-cell lymphoma gene encoding the E3-