Key result
Treatment with propolis significantly improved cardiotoxicity induced by 5-fluorouracil in rats, reducing ST-segment elevation, oxidative stress, and histopathological degenerations.
Why the study?
5-Fluorouracil is a common cause of chemotherapy-induced cardiotoxicity, and propolis was investigated to evaluate its cardioprotective effects against this toxicity.
Does propolis reduce 5-fluorouracil-induced cardiotoxicity in a rat model?
Does propolis reduce 5-fluorouracil-induced cardiotoxicity in a rat model?
Absolute Event Rate: 217.2% vs 457.8%
p-value: p=<0.0001
Propolis demonstrates significant cardioprotective effects against 5-fluorouracil-induced toxicity in rats by reducing oxidative stress, inflammation, and ECG abnormalities.
Supports preclinical cardioprotection by propolis vs 5-FU; leaves open translation to human cardiotoxicity prevention.
5-Fluorouracil (5-FU) is one of the most common chemotherapeutic agents used in treating solid tumors, and the 5-FU-induced cardiotoxicity is the second cause of cardiotoxicity induced by chemotherapeutic drugs. Propolis (Pro) has vigorous anti-inflammatory activity. Its cardio-protective characteristic against doxorubicin-induced cardiotoxicity was previously proven. The current study aimed to appraise the effect of Pro on 5-FU-induced cardiotoxicity in rats. Twenty-four male Wistar rats were divided into four groups: Control, 5-FU, 5-FU + Pro 250 mg/kg, and 5-FU + Colchicine (CLC) 5 mg/kg. Different hematological, serological, biochemical, histopathological, and molecular assays were performed to assess the study's aim. Moreover, a rat myocardium (H9C2(2-1)) cell line was also used to assess this protective effect in-vitro. 5-FU resulted in significant cardiotoxicity represented by an increase in malondialdehyde (MDA) levels, cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) expression, cardiac enzyme levels, and histopathological degenerations. 5-FU treatment also decreased bodyweight, total anti-oxidant capacity (TAC), catalase (CAT) levels, blood cell counts, and hemoglobin (Hb) levels. In addition, 5-FU disrupted ECG parameters, including increased elevation in the ST-segment and increased QRS complex and QTc duration. Treating with Pro reduced oxidative stress, cardiac enzymes, histopathological degenerations, and COX-2 expression in cardiac tissue alleviated ECG disturbances and increased the number of blood cells and TAC levels. Moreover, 5-FU-induced bodyweight loss was ameliorated after treatment with Pro. Our results demonstrated that treatment with Pro significantly improved cardiotoxicity induced by 5-FU in rats.
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Barary et al. (2022) studied 5-fluorouracil-induced cardiac toxicity (n=24). Propolis vs. 5-fluorouracil alone was evaluated on ST-segment (mV) (p=<0.0001). Treatment with propolis significantly improved cardiotoxicity induced by 5-fluorouracil in rats, reducing ST-segment elevation, oxidative stress, and histopathological degenerations.
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