Key result
Intravenous 5-fluorouracil induced ECG abnormalities in 100% of guinea pigs at 60 mg/kg and 44.4% at 30 mg/kg, associated with myocardial high-energy phosphate depletion and citrate accumulation.
Why the study?
Does 5-fluorouracil induce ischemic ECG changes and metabolic alterations in the myocardium of guinea pigs?
Population
Anesthetized open-chest guinea pigs
Design
Preclinical
Follow-up
up to 5 hours
Authors
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May indicate metabolic mechanism in guinea pigs; leaves open human relevance and clinical translation.
Does 5-fluorouracil induce ischemic ECG changes and metabolic alterations in the myocardium of guinea pigs?
5-fluorouracil induces ischemic ECG changes in guinea pigs, likely driven by aconitase inhibition and subsequent depletion of high-energy phosphates in the myocardium.
Matsubara et al. (1980) studied Cardiotoxicity. 5-fluorouracil (5-FU) was evaluated on Incidence of ECG abnormality. Intravenous 5-fluorouracil induced ECG abnormalities in 100% of guinea pigs at 60 mg/kg and 44.4% at 30 mg/kg, associated with myocardial high-energy phosphate depletion and citrate accumulation.