Key result
Intravenous 5-fluorouracil induced massive hemorrhagic myocardial infarcts at a single 50 mg/kg dose, and left ventricular hypertrophy with disseminated apoptosis at repeated 15 mg/kg doses.
Why the study?
What are the mechanisms of 5-fluorouracil-induced cardiotoxicity in a rabbit model?
What are the mechanisms of 5-fluorouracil-induced cardiotoxicity in a rabbit model?
5-fluorouracil cardiotoxicity is driven not only by coronary artery spasm but also by apoptosis of myocardial and endothelial cells, which can result in inflammatory lesions mimicking toxic myocarditis.
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Apoptosis may contribute to 5FU cardiotoxicity beyond spasm in rabbits; leaves open relevance to patients and need for human studies.
Tsibiribi et al. (2006) studied 5-fluorouracil cardiotoxicity (n=18). 5-fluorouracil vs. Control group was evaluated on Macroscopic and microscopic examinations of the heart and apoptosis by the TUNEL method. Intravenous 5-fluorouracil induced massive hemorrhagic myocardial infarcts at a single 50 mg/kg dose, and left ventricular hypertrophy with disseminated apoptosis at repeated 15 mg/kg doses.
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