What question did this study set out to answer?

To evaluate the clinical features and pathophysiological mechanism of 5-fluorouracil cardiotoxicity mimicking acute myocardial infarction.

January 1, 1995Japanese Circulation Journal-english EditionOpen Access

A Case of 5-Fluorouracil Cardiotoxicity Simulating Acute Myocardial Infarction.

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Population

1 patient with 5-fluorouracil (5-FU) cardiotoxicity simulating acute myocardial infarction

Design

Case_report

Authors

YMYuji MizunoHeart Failure / Cardiomyopathy YHYoichi Hokamura TKTadashi KimuraJikei University School of Medicine

Discussion

Member takes

Implication

Questions spasm as mechanism in 5-FU cardiotoxicity mimicking MI; hypothesis-generating, should not yet change practice.

Key Points

To evaluate the clinical features and pathophysiological mechanism of 5-fluorouracil cardiotoxicity mimicking acute myocardial infarction.
Assessed a cancer patient who developed severe resting chest pain and ischemic electrocardiographic abnormalities while undergoing 5-fluorouracil chemotherapy.
Conducted coronary angiography, left ventricular angiography, and continuous cardiac biomarker tracking during a prolonged symptomatic attack.
The patient presented with chest pain refractory to calcium-channel blockers accompanied by a slow increase in cardiac enzyme levels.
Angiographic findings during the prolonged cardiac episode showed no evidence of coronary artery spasm or ischemic occlusion.

Structured PICO

Population

1 patient with 5-fluorouracil (5-FU) cardiotoxicity simulating acute myocardial infarction

Intervention

5-Fluorouracil (5-FU)

Outcome

Mechanism of cardiotoxicity assessed via clinical findings, coronary angiography, and left ventricular angiography

This case report suggests that 5-fluorouracil-induced cardiotoxicity simulating acute myocardial infarction may not be caused by coronary artery spasm.

Cite This Study

Mizuno et al. (1995) studied this question.

synapsesocial.com/papers/6a711cd3660549caf2c5bef0 https://doi.org/10.1253/jcj.59.303

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A Case of 5-Fluorouracil Cardiotoxicity Simulating Acute Myocardial Infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A Case of 5-Fluorouracil Cardiotoxicity Simulating Acute Myocardial Infarction.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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