Key result
A 56-year-old male with advanced colorectal cancer and no prior heart disease developed an acute myocardial infarction due to coronary artery spasm during 5-fluorouracil infusion.
Case Report (n=1)
5-fluorouracil infusion can cause acute myocardial infarction secondary to coronary artery spasm, highlighting the need for tight clinical monitoring during administration.
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5-Fluorouracil may trigger coronary spasm and infarction; single case leaves open need for monitoring protocols or risk mitigation in oncology.
Cardiac toxicity is an uncommon side-effect of 5-fluorouracil (5-FU) treatment, consisting mainly of chest pain episodes with or without electrocardiographic changes and dysrhythmias. Here, we describe the case of a 56-year-old male patient with a diagnosis of advanced colorectal cancer who developed an acute myocardial infarction during 5-FU infusion. The patient was not affected by prior heart disease and did not show any classic risk factors for coronary heart disease. Coronary angiography examination revealed no evidence of coronary stenosis, supporting the hypothesis of a coronary artery spasm related to 5-FU infusion. Given the great number of cancer patients receiving 5-FU containing chemotherapeutic regimens, this rare but severe cardiac side-effect may be observed in both cardiologic and oncologic clinical practice. We suggest a tight clinical monitoring of all patients receiving 5-FU infusions, even in those without a prior history of heart disease.
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Canale et al. (2006) conducted a case report in Advanced colorectal cancer (n=1). 5-fluorouracil (5-FU) infusion was evaluated on Acute myocardial infarction. A 56-year-old male with advanced colorectal cancer and no prior heart disease developed an acute myocardial infarction due to coronary artery spasm during 5-fluorouracil infusion.
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