Why the study?
What is the incidence and clinical presentation of life-threatening cardiac toxicity in patients treated with 5-fluorouracil?
Population
Approximately 910 patients treated with 5-fluorouracil during a 16-month period
Design
Cohort
Authors
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Clinicians should monitor for ischemia during 5-FU therapy; this Level 3 observation leaves open questions on incidence and prevention.
What is the incidence and clinical presentation of life-threatening cardiac toxicity in patients treated with 5-fluorouracil?
5-fluorouracil therapy is associated with a rare (0.55%) but life-threatening risk of cardiotoxicity, likely driven by coronary vasospasm leading to ischemia, infarction, and arrhythmias.
Keefe et al. (1993) studied this question.
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