Key result
5-fluorouracil chemotherapy caused sudden onset of severe cardiac failure in a 23-year-old patient, with biopsy showing sarcoplasmic reticulum proliferation and marked vacuolization.
Population
1 previously healthy 23-year-old patient with squamous cell carcinoma of the tongue
Design
Case_report
Authors
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Alerts clinicians to rare acute nonischemic HF with 5-FU even in young adults; single case leaves open questions on incidence and prevention.
Case Report (n=1)
This case report highlights the potential for severe, non-ischemic heart failure induced by 5-fluorouracil, supported by endomyocardial biopsy findings.
Kuropkat et al. (1999) conducted a case report in Squamous cell carcinoma of the tongue (n=1). 5-fluorouracil (5-FU) was evaluated. 5-fluorouracil chemotherapy caused sudden onset of severe cardiac failure in a 23-year-old patient, with biopsy showing sarcoplasmic reticulum proliferation and marked vacuolization.
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