Why the study?
5-Fluorouracil can cause a wide spectrum of cardiotoxicity ranging from asymptomatic electrocardiographic changes to cardiomyopathy and heart failure.
Does 5-fluorouracil induce cardiotoxicity in patients treated for solid tumors?
Does 5-fluorouracil induce cardiotoxicity in patients treated for solid tumors?
Answers are grounded in this paper and cite their sources.
5-Fluorouracil can cause severe but potentially reversible cardiotoxicity, including cardiomyopathy, emphasizing the critical need for early recognition and prompt discontinuation of the drug.
BACKGROUND: 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. Main body of the abstract: We present two descriptive cases of new-onset severe cardiomyopathy induced by 5-FU followed by a review of the literature. CONCLUSION: Our case series emphasizes the importance of early recognition of this rare complication and prompt cessation of 5-FU, as cardiac dysfunction in this context is potentially reversible.
No takes yet. Share an insight, caveat, or question.
Yuan et al. (2019) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: