What is the clinical evidence from this study?

Study design: Case Report. Population: Acute heart failure with cardiogenic shock (n=1). Intervention: 5-Fluorouracil (5-FU). Primary outcome: Acute heart failure with cardiogenic shock.

What does this research mean for the field?

5-Fluorouracil exposure can induce severe acute heart failure with cardiogenic shock that is reversible upon discontinuation of therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a case of severe acute heart failure and cardiogenic shock linked to 5-fluorouracil chemotherapy and evaluate recovery following drug discontinuation.

September 18, 2026Case Reports in CardiologyOpen Access

5‐Fluorouracil (5‐FU) Cardiotoxicity: A Stressful Event

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Key result

5-fluorouracil exposure linked to acute heart failure and cardiogenic shock that resolves upon cessation.

Population

1 56-year-old man who developed acute heart failure with cardiogenic shock suspected to be related to…

Design

Case_report

Authors

YDYash DesaiHoward Hughes Medical Institute RSRohan SinghRutgers, The State University of New Jersey KDKush DesaiMarshall University

Discussion

Member takes

Implication

5-FU cardiotoxicity may resolve with prompt cessation; single case leaves open incidence, risk stratification, and prospective validation.

Key Points

To describe a case of severe acute heart failure and cardiogenic shock linked to 5-fluorouracil chemotherapy and evaluate recovery following drug discontinuation.
Documented the clinical management and outcomes of a 56-year-old male with solid tumor malignancy presenting with cardiogenic shock after 5-fluorouracil administration.
Evaluated hemodynamic and myocardial recovery following the immediate discontinuation of chemotherapy.
The patient experienced acute heart failure with cardiogenic shock directly suspected to arise from 5-fluorouracil cardiotoxicity.
Myocardial dysfunction and shock resolved fully following the cessation of 5-fluorouracil treatment.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 56-year-old man who developed acute heart failure with cardiogenic shock suspected to be related to 5-fluorouracil exposure.

Exposure

Cessation of 5-Fluorouracil (5-FU) therapy

Outcome

Resolution of cardiac dysfunction

5-Fluorouracil (5-FU) can induce severe but potentially reversible cardiotoxicity, including acute heart failure with cardiogenic shock.

Cite This Study

Desai et al. (2026) conducted a case report in Acute heart failure with cardiogenic shock (n=1). 5-Fluorouracil (5-FU) was evaluated on Acute heart failure with cardiogenic shock. Exposure to 5-fluorouracil in a 56-year-old man was associated with acute heart failure and cardiogenic shock, which resolved following cessation of therapy.

synapsesocial.com/papers/6aacf5ed0c46fbdff987dd5c https://doi.org/10.1155/cric/2215209

Topics

Heart failure HFrEF treatment

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Implication

5-FU cardiotoxicity may resolve with prompt cessation; single case leaves open incidence, risk stratification, and prospective validation.

5‐Fluorouracil (5‐FU) Cardiotoxicity: A Stressful Event

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

5‐Fluorouracil (5‐FU) Cardiotoxicity: A Stressful Event

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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