Key result
5-fluorouracil administration caused coronary vasospasm mimicking acute myocardial infarction, which resolved rapidly following the administration of nitroglycerin and diltiazem.
Case Report (n=1)
5-fluorouracil administration can cause coronary vasospasm mimicking acute myocardial infarction, which can be successfully treated with nitrates and calcium channel blockers.
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Warrants vigilance for 5-FU vasospasm during infusions; single case leaves open incidence, risk factors, and prevention.
5-Fluorouracil is the key chemotherapeutic agent used in the treatment of adenocarcinomas of the gastrointestinal system. However, serious cardiac side effects related to 5-fl uorouracil treatment including coronary vasospasm, thrombosis, myocardial infarction, cardiomyopathy and sudden death have been reported previously. The incidence of cardiotoxic effects depends on the dose and route of application.
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Tekiner et al. (2015) conducted a case report in Colon cancer with suspected myocardial infarction (n=1). 5-Fluorouracil was evaluated on Development of coronary vasospasm. 5-fluorouracil administration caused coronary vasospasm mimicking acute myocardial infarction, which resolved rapidly following the administration of nitroglycerin and diltiazem.
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