Key result
5-fluorouracil triggers acute coronary syndrome via coronary vasospasm that resolves with nitrates.
Why the study?
Cardiotoxicity from 5-fluorouracil is uncommon and its underlying mechanisms, including coronary vasospasm, are not fully understood.
Does 5-fluorouracil induce coronary artery spasm in patients receiving chemotherapy?
Population
One woman receiving 5-fluorouracil therapy
Comparison
Exposure to 5-fluorouracil with coronary spasm vs no spasm
Design
Case report
Authors
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Supports nitrate consideration in suspected cases; single report leaves incidence and prevention open.
Case Report (n=1)
Does 5-fluorouracil induce coronary artery spasm in patients receiving chemotherapy?
5-fluorouracil can induce coronary artery spasm presenting as acute coronary syndrome, which may resolve with nitrate therapy.
Görgülü et al. (2002) conducted a case report in Coronary artery spasm (n=1). 5-fluorouracil was evaluated on Coronary spasm. 5-fluorouracil therapy induced a coronary spasm presenting as acute coronary syndrome, which resolved with nitrate therapy.
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