Impact of HALP score on long-term clinical outcomes in patients with coronary bifurcation lesion undergoing 2-stent strategy

Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient's nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure. A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups. HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality. Our study's findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.