Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 14, 2026

The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and prognosis in patients with heart failure: A retrospective analysis of the MIMIC-IV database.

View Full Paper
Ask AI
Bookmark
Share

Key result

Higher HALP score linked to ~14% lower short-term mortality in ICU heart failure patients.

  • n=4,286

Why the study?

Is a higher HALP score associated with reduced ICU/hospital length of stay and mortality in patients with heart failure admitted to the ICU?

Population

4286 patients with heart failure admitted to the intensive care unit, average age 73.12 years, 41.8% female.

Comparison

Higher hemoglobin, albumin, lymphocyte, and… vs Lower HALP score

Design

Cohort

Follow-up

365 days

Authors

KZKe ZhenCapital Medical UniversityJLJiangtao LiCapital Medical UniversityHJHongfeng JiangCapital Medical University

Discussion

Loading...

Member takes

Implication

A higher HALP score is associated with shorter ICU and hospital length of stay and lower short- and long-term mortality in ICU-admitted heart failure patients.

Key Points

  • This study investigates the relationship between HALP score and clinical outcomes in heart failure patients admitted to the ICU.
  • Retrospective analysis using MIMIC-IV database data from 4286 patients with heart failure.
  • Patients were categorized into quartiles based on HALP scores to evaluate associations with ICU and hospital length of stay and mortality.
  • Analyses included Kaplan-Meier survival curves, Cox proportional hazards, and restricted cubic spline to explore relationships.
  • Each 10-unit increase in HALP score was associated with a 0.19-day reduction in ICU LOS (p<0.001) and 0.15-day reduction in hospital LOS (p<0.001).
  • A 10-unit increase in HALP score led to a 14% reduction in 28-day mortality (unadjusted) and a 13% reduction in 365-day mortality (p<0.001).
  • Higher HALP scores consistently correlated with shorter ICU and hospital stays and lower mortality across quartiles.

Study Design

Type

Cohort (n=4,286)

Structured PICO

Is a higher HALP score associated with reduced ICU/hospital length of stay and mortality in patients with heart failure admitted to the ICU?

P
Population
4,286 patients with heart failure admitted to the ICU (mean age 73.12 years, 41.8% female) identified from the MIMIC-IV database.
E
Exposure
Higher hemoglobin, albumin, lymphocyte, and platelet (HALP) score
C
Comparator
Lower HALP score
O
Outcome
ICU length of stay (LOS), hospital LOS, 28-day mortality, and 365-day mortalityhard clinical

A higher HALP score is associated with shorter ICU and hospital length of stay and lower short- and long-term mortality in ICU-admitted heart failure patients.

Cite This Study

Zhen et al. (2026) conducted a cohort in Heart failure (n=4,286). Hemoglobin, albumin, lymphocyte, and platelet (HALP) score vs. Lower HALP scores was evaluated on ICU length of stay, hospital length of stay, 28-day mortality, and 365-day mortality. Each 10-unit increase in HALP score was associated with a 0.19-day reduction in ICU length of stay and a 14% reduction in short-term mortality in ICU patients with heart failure.

synapsesocial.com/papers/6a056824a550a87e60a207fchttps://doi.org/10.1097/md.0000000000048530
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigation of the Usefulness of HALP Score in Predicting Short-Term Mortality in Patients with Acute Decompensated Heart Failure in a Coronary Care Unit2024 · 13 citations
  2. 2Association Between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Adverse Outcomes in Critically Ill Patients With Acute Myocardial Infarction: A Retrospective Study and Machine Learning Analysis2025 · 3 citations
  3. 3Is HALP score a predictor of poor prognosis in patients with hematologic malignancies admitted to the intensive care unit?2024 · 2 citations
  4. 4The L-shaped relationship between HALP score and one-year mortality in critically ill surgical patients: a retrospective cohort study2025 · 2 citations
  5. 5A Potential Relationship Between HALP Score and In‐Hospital Mortality in Acute Heart Failure2025 · 10 citations