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July 4, 2025Scientific ReportsOpen Access

Compared to the lowest HALP quartile, the fully adjusted ORs for 1-year mortality were 0.74 (95% CI 0.64-0.86) for Q2, 0.58 (95% CI 0.50-0.69) for Q3, and 0.46 (95% CI 0.39-0.55) for Q4 (p<0.001).

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Why the study?

The HALP score is a composite biomarker reflecting systemic inflammatory and nutritional status with prognostic significance, but its association with 12-month mortality in critically ill surgical patients needed specific investigation.

Does the HALP score predict one-year mortality in critically ill surgical patients?

Population

8,052 critically ill surgical patients from the Taichung Veterans General Hospital Critical Care Database

Comparison

HALP score levels and quartiles

Design

Retrospective cohort study

Follow-up

12 months

Authors

HXHao XiaJLJiawei LaiJLJinzhan Lin

Discussion

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Member takes

Overview

May aid mortality risk stratification in surgical ICU patients; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Does the HALP score predict one-year mortality in critically ill surgical patients?

P
Population
8,052 critically ill surgical patients admitted to surgical intensive care units (SICUs), mean age 61.0, 62.6% male, Taiwan-based. Excluded: admission duration <24 hours and organ transplant recipients.
I
Intervention
HALP (hemoglobin, albumin, lymphocyte, and platelet) score assessment
C
Comparator
Higher HALP score quartiles (Q2, Q3, Q4) compared to the lowest quartile (Q1: 1.7-22.2)
O
Outcome
One-year all-cause mortality evaluated by death registry datahard clinical

Lower HALP scores are independently associated with a higher risk of one-year mortality in critically ill surgical patients, demonstrating an L-shaped nonlinear relationship.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/6a813fbb9fceb4fbd5e3dfcahttps://doi.org/10.1038/s41598-025-93821-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effectiveness of HALP score in predicting mortality in non-ST-elevation myocardial infarction patients2024 · 9 citations
  2. 2The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and prognosis in patients with heart failure: A retrospective analysis of the MIMIC-IV database.2026
  3. 3Exploring the J-shaped relationship between HALP score and mortality in cancer patients: A NHANES 1999-2018 cohort study2024 · 19 citations
  4. 4Is HALP score a predictor of poor prognosis in patients with hematologic malignancies admitted to the intensive care unit?2024 · 2 citations
  5. 5Association Between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Adverse Outcomes in Critically Ill Patients With Acute Myocardial Infarction: A Retrospective Study and Machine Learning Analysis2025