Key result
Continuous infusion of 5-fluorouracil was associated with marked coronary vasospasm on cardiac catheterization, supporting the vasospastic hypothesis for 5-FU-induced angina.
Why the study?
Does continuous infusion of 5-fluorouracil cause coronary vasospasm in patients with metastatic colon cancer?
Population
63-year-old man treated for metastatic colon cancer (n=1)
Design
Case_report
Authors
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Hypothesis-generating in one case; leaves open whether vasospasm is causal or warrants practice changes.
Case Report (n=1)
Does continuous infusion of 5-fluorouracil cause coronary vasospasm in patients with metastatic colon cancer?
This case report supports the hypothesis that 5-fluorouracil-induced cardiotoxicity is mediated by coronary vasospasm, a potentially lethal side effect requiring prompt discontinuation of the drug.
Shoemaker et al. (2004) conducted a case report in Metastatic colon cancer (n=1). 5-fluorouracil (5-FU) was evaluated on Coronary vasospasm. Continuous infusion of 5-fluorouracil was associated with marked coronary vasospasm on cardiac catheterization, supporting the vasospastic hypothesis for 5-FU-induced angina.
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