Key result
A 56-year-old man developed severe multivessel coronary vasospasm mimicking ST-segment elevation myocardial infarction secondary to 5-fluorouracil chemotherapy.
Why the study?
Five-fluorouracil is frequently used for colonic carcinoma, but in rare cases may cause cardiotoxicity ranging from asymptomatic electrocardiographic changes to overt ischemia.
Case Report (n=1)
5-fluorouracil can cause severe multivessel coronary vasospasm that mimics ST-segment elevation myocardial infarction, highlighting the need for awareness of this cardiotoxic effect.
Alerts to 5-FU cardiotoxicity risk in CAD patients on chemotherapy; leaves open prospective monitoring studies.
Five-fluorouracil (5-FU) is frequently used in antineoplastic regimen, especially for colonic carcinoma. In rare cases, 5-FU may be associated with cardiotoxicity ranging from asymptomatic electrocardiographic changes to overt ischemia.1 A 56-year-old man with a history of hypertension, hyperlipidemia, cecal carcinoma on chemotherapy, and coronary artery disease (CAD) with prior right coronary artery stents presented with chest discomfort of 1-day duration. The chest discomfort worsened when he tried to stand.
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Mehta et al. (2023) conducted a case report in Coronary vasospasm secondary to 5-fluorouracil (n=1). 5-Fluorouracil (5-FU) was evaluated. A 56-year-old man developed severe multivessel coronary vasospasm mimicking ST-segment elevation myocardial infarction secondary to 5-fluorouracil chemotherapy.
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