Why the study?
Does high-dose 5-fluorouracil infusion cause symptomatic cardiotoxicity in patients with malignancies?
Does high-dose 5-fluorouracil infusion cause symptomatic cardiotoxicity in patients with malignancies?
High-dose 5-fluorouracil infusion is associated with an 8% risk of symptomatic, but generally reversible, cardiotoxicity in patients without underlying cardiac disease.
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Supports cardiac monitoring during high-dose 5-FU; leaves open the need for prospective trials to define incidence and risk factors.
Akhtar et al. (2009) studied this question.
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