This case report highlights the potential for 5-fluorouracil therapy to cause myocardial infarction, possibly through endoarteritis rather than atherosclerosis.
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Alerts clinicians to possible 5-FU-related MI without atherosclerosis; leaves open endoarteritis mechanism for prospective study.
We report the case of a patient bearing a sigmoid colon carcinoma, stage IV, who after 11 months of antiblastic therapy, having completed a dose of 81,000 mg of 5-FU and CCNU, suffered a myocardial infarct. We attribute this complication to 5-FU. Due to the fact that the coronary angiogram did not confirm the arteriosclerotic nature of the lesion, we suggest that it could have been caused by an endoarteritis, resulting from an immuno-allergic or toxic cumulative process.
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Rabinovich et al. (1985) studied this question.
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